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<front><journal-meta><journal-id journal-id-type="publisher-id">J Mov Neuromuscul Sci.</journal-id><journal-title-group><journal-title>Journal of Movement &amp; Neuromuscular Science</journal-title><abbrev-journal-title>J Mov Neuromuscul Sci.</abbrev-journal-title></journal-title-group><issn pub-type="epub">REQUIRED_MISSING</issn><publisher><publisher-name>Noventra Scientific Publishing</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">REQUIRED_MISSING</article-id><article-categories><subj-group subj-group-type="heading"><subject>Clinical &amp; Applied Movement Sciences</subject></subj-group></article-categories><title-group><article-title>The Evidence Landscape of Paralympic Sport Science: An Umbrella Review Across Major Research Domains</article-title></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8409-868X</contrib-id><name name-style="western"><surname>Bragazzi</surname><given-names>Nicola Luigi</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8031-3792</contrib-id><name name-style="western"><surname>Taheri</surname><given-names>Morteza</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3419-0669</contrib-id><name name-style="western"><surname>Trompetto</surname><given-names>Carlo</given-names></name><xref ref-type="aff" rid="aff3">3</xref><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0825-2707</contrib-id><name name-style="western"><surname>Puce</surname><given-names>Luca</given-names></name><xref ref-type="aff" rid="aff3">3</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib></contrib-group><aff id="aff1"><label>1</label><institution-wrap><institution>Department of Mathematics and Statistics, Laboratory for Industrial and Applied Mathematics (LIAM), York University</institution></institution-wrap><addr-line>Toronto, Ontario (ON)</addr-line><country>Canada</country></aff><aff id="aff2"><label>2</label><institution-wrap><institution>Department of Motor Behavior, Faculty of Sport Sciences and Health, University of Tehran</institution></institution-wrap><addr-line>Tehran</addr-line><country>Iran</country></aff><aff id="aff3"><label>3</label><institution-wrap><institution>Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa</institution></institution-wrap><country>Italy</country></aff><aff id="aff4"><label>4</label><institution-wrap><institution>IRCCS Azienda Ospedaliera Metropolitana</institution></institution-wrap><addr-line>Genoa</addr-line><country>Italy</country></aff><author-notes><corresp id="cor1">Corresponding author: <email>luca.puce@medicina.unige.it</email></corresp></author-notes><pub-date pub-type="epub"><day>28</day><month>9</month><year>2026</year></pub-date><volume>1</volume><issue>2</issue><elocation-id>REQUIRED_MISSING</elocation-id><history><date date-type="received"><day>15</day><month>6</month><year>2026</year></date><date date-type="rev-recd"><day>25</day><month>8</month><year>2026</year></date><date date-type="accepted"><day>8</day><month>9</month><year>2026</year></date></history><permissions><copyright-statement>© 2026 The Author(s)</copyright-statement><copyright-year>2026</copyright-year><license license-type="REQUIRED_MISSING" xlink:href="REQUIRED_MISSING"><license-p>REQUIRED_MISSING</license-p></license></permissions><related-article related-article-type="has-supplement" ext-link-type="uri" xlink:href="../supplementary/">Supplementary material</related-article><abstract><p>Background: Paralympic sport science has expanded, but evidence remains fragmented across sports, impairments, research domains, and methods. We aimed to synthesize this evidence, evaluate its credibility and overlap, and identify research priorities.</p><p>Methods: Six databases were searched to 30 June 2026. Two reviewers independently screened records. Systematic reviews relevant to competitive Para sport were included. ROBIS, AMSTAR 2, corrected covered area, and secondary injury and VO₂peak re-analyses were used.</p><p>Results: Thirty-eight systematic reviews (2012-2026) were included across five domains. Injury evidence showed a substantial, heterogeneous burden, with recurrent upper-limb and shoulder problems in wheelchair and sitting sports. Physiological and training evidence showed sport-, impairment-, sex-, and protocol-related variation; supplementation, sleep, and recovery evidence remained limited. Testing and classification reviews showed stronger evidence for reliability than for validity, responsiveness, or class-specific interpretation. Biomechanical and technology studies highlighted task- and equipment-dependent performance, whereas psychological and system-level reviews identified psychosocial, coaching, accessibility, financial, and infrastructural determinants, although evidence was frequently cross-sectional or indirect. ROBIS rated 11 reviews low risk, 23 high risk, and 4 unclear; AMSTAR 2 confidence was moderate in 2, low in 3, and critically low in 5. Primary-study overlap was moderate (CCA 7.6%). Secondary analyses estimated injury prevalence at 41.9% and incidence at 13.4 per 1,000 athlete-days, both with wide prediction intervals; sport-specific normalized VO₂peak estimates ranged from 17.4 to 45.3 mL/kg/min.</p><p>Conclusions: The evidence base is broad but methodologically uneven and strongly context-dependent. Greater standardization and sport- and impairment-specific research are needed to improve comparability and relevance.</p></abstract><kwd-group kwd-group-type="author-generated"><kwd>Paralympic sport</kwd><kwd>Para sport</kwd><kwd>umbrella review</kwd><kwd>secondary meta-analysis</kwd><kwd>VO₂peak</kwd><kwd>injury</kwd><kwd>classification</kwd><kwd>biomechanics</kwd><kwd>assistive technology</kwd><kwd>performance testing</kwd><kwd>evidence mapping</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>funding</meta-name><meta-value>This research received no external funding.</meta-value></custom-meta><custom-meta><meta-name>ethics</meta-name><meta-value>Not applicable; this study synthesized published literature and did not involve new human-participant data.</meta-value></custom-meta><custom-meta><meta-name>consent</meta-name><meta-value>Not applicable.</meta-value></custom-meta><custom-meta><meta-name>data-availability</meta-name><meta-value>The de-identified processed datasets, complete analysis tables, and analysis code supporting the findings of this study are available from the corresponding author upon reasonable request.</meta-value></custom-meta><custom-meta><meta-name>competing-interests</meta-name><meta-value>The authors declare no commercial, financial, or other relationships that could be construed as a potential conflict of interest.</meta-value></custom-meta><custom-meta><meta-name>credit</meta-name><meta-value>Nicola Luigi Bragazzi: Conceptualization; Methodology; Formal analysis; Visualization; Writing – original draft; Writing – review &amp; editing. Morteza Taheri: Screening; Data curation; Validation; Writing – review &amp; editing. Carlo Trompetto: Methodology; Validation; Supervision; Writing – review &amp; editing. Luca Puce: Conceptualization; Supervision; Project administration; Writing – review &amp; editing.</meta-value></custom-meta><custom-meta><meta-name>acknowledgements</meta-name><meta-value>The authors have no acknowledgements to report.</meta-value></custom-meta><custom-meta><meta-name>trial-registration</meta-name><meta-value>PROSPERO CRD420261387208.</meta-value></custom-meta><custom-meta><meta-name>ai-disclosure</meta-name><meta-value>Generative AI tools were used only for editorial preparation and formatting support. The authors reviewed and approved the final content and take full responsibility for the work.</meta-value></custom-meta></custom-meta-group></article-meta></front><body>
<sec id="introduction">
  <title>1. Introduction</title>
  <p>Paralympic sport science has expanded considerably alongside the
  development of competitive Para sport and now encompasses athlete
  health, physiology, training, nutrition, performance assessment,
  classification, biomechanics, assistive technology, recovery, and
  psychological and system-level determinants. This multidisciplinary
  growth reflects the complexity of high-performance Para sport, in
  which performance and health outcomes are shaped not only by training
  and competitive demands but also by impairment characteristics, sport
  class, equipment, and the interaction between the athlete and the
  specific task
  [<xref alt="1" rid="ref-1" ref-type="bibr">1</xref>,
  <xref alt="2" rid="ref-2" ref-type="bibr">2</xref>,
  <xref alt="3" rid="ref-3" ref-type="bibr">3</xref>].</p>
  <p>A defining feature of Para sport is that performance cannot be
  interpreted independently of eligible impairment and classification.
  Classification determines eligibility and aims to minimize the
  influence of impairment on competition outcome, requiring
  sport-specific evidence linking impairment to activity limitation
  rather than diagnosis alone
  [<xref alt="4" rid="ref-4" ref-type="bibr">4</xref>,
  <xref alt="5" rid="ref-5" ref-type="bibr">5</xref>,
  <xref alt="6" rid="ref-6" ref-type="bibr">6</xref>,
  <xref alt="7" rid="ref-7" ref-type="bibr">7</xref>]. At
  the same time, wheelchairs, prostheses, throwing frames, seating
  systems, and other assistive technologies may influence movement
  strategies, mechanical loading, and performance itself
  [<xref alt="2" rid="ref-2" ref-type="bibr">2</xref>]. These
  interactions make direct comparisons across sports and athlete groups
  particularly challenging.</p>
  <p>The same problem applies to health, physiological, and performance
  indicators. Injury estimates vary according to sport, impairment,
  exposure definition, and surveillance method
  [<xref alt="8" rid="ref-8" ref-type="bibr">8</xref>,
  <xref alt="9" rid="ref-9" ref-type="bibr">9</xref>],
  whereas cardiorespiratory responses and aerobic capacity vary
  substantially across Para-sport disciplines and are influenced by sex,
  impairment, exercise mode, and testing protocol
  [<xref alt="10" rid="ref-10" ref-type="bibr">10</xref>,
  <xref alt="11" rid="ref-11" ref-type="bibr">11</xref>].
  Performance tests and classification-related measures also differ
  markedly in their reliability, validity, responsiveness, and relevance
  to specific sport classes
  [<xref alt="12" rid="ref-12" ref-type="bibr">12</xref>,
  <xref alt="13" rid="ref-13" ref-type="bibr">13</xref>].
  Consequently, findings obtained in one sport, impairment group, or
  testing context cannot automatically be generalized to the wider
  Paralympic population.</p>
  <p>Over the past decade, systematic reviews have increasingly
  synthesized individual areas of this literature, including injury and
  illness, physiology and training, testing and classification,
  biomechanics and technology, and psychological and system-level
  factors [<xref alt="2" rid="ref-2" ref-type="bibr">2</xref>,
  <xref alt="6" rid="ref-6" ref-type="bibr">6</xref>,
  <xref alt="8" rid="ref-8" ref-type="bibr">8</xref>,
  <xref alt="10" rid="ref-10" ref-type="bibr">10</xref>,
  <xref alt="14" rid="ref-14" ref-type="bibr">14</xref>].
  However, these bodies of evidence have largely developed in parallel.
  Reviews often focus on specific sports, impairments, outcomes, or
  methodological traditions, and many include broader disability-sport,
  recreational, or clinical populations alongside competitive Para
  athletes. As a result, the overall evidence landscape remains
  difficult to interpret: it is unclear which findings are consistently
  supported across the literature, which are confined to particular
  contexts, and where important gaps remain.</p>
  <p>A comprehensive synthesis across research domains is therefore
  important not simply to summarize the volume of existing evidence, but
  to determine how mature, coherent, and directly applicable that
  evidence is to competitive Para sport. Such an overview can identify
  areas in which findings converge, highlight domains in which evidence
  remains sparse or inconsistent, and clarify where apparent
  generalizations are limited by sport-, impairment-, class-, sex-,
  equipment-, or protocol-specific factors. This broader perspective is
  also necessary for setting research priorities and for translating an
  increasingly large but heterogeneous literature into more defensible
  decisions in athlete monitoring, health protection, performance
  assessment, classification, and training.</p>
  <p>The aim of this umbrella review was to map and critically
  synthesize systematic-review evidence relevant to competitive
  Paralympic sport across major research domains, evaluate the breadth,
  consistency, credibility, and applicability of the available evidence,
  and identify well-supported conclusions, unresolved gaps, and
  priorities for future research and practice.</p>
</sec>
<sec id="methods">
  <title>2. Methods</title>
  <sec id="design-and-reporting-approach">
    <title>2.1 Design and reporting approach</title>
    <p>This study was conducted as an umbrella review of systematic
    reviews and meta-analyses and is reported in accordance with PRISMA
    2020 and the PRIOR statement
    [<xref alt="15" rid="ref-15" ref-type="bibr">15</xref>,
    <xref alt="16" rid="ref-16" ref-type="bibr">16</xref>]. The
    protocol was prospectively registered in PROSPERO (CRD420261387208).
    The review question, eligibility criteria, and review-level unit of
    evidence remained unchanged throughout the study. During conduct of
    the review, the methodological appraisal strategy was refined by
    applying ROBIS across the heterogeneous review corpus and
    restricting AMSTAR 2 to reviews falling within its intended scope.
    Primary-study overlap was also quantified using corrected covered
    area (CCA), and selected secondary quantitative re-analyses were
    added to examine numerical data reported within included reviews.
    These additions did not alter eligibility, study selection, or the
    composition of the review corpus.</p>
    <p>Systematic reviews were the unit of evidence. Because
    populations, sports, impairments, methods, and outcomes were
    structurally heterogeneous, the principal synthesis was descriptive
    and interpretive. Secondary quantitative analyses were restricted to
    numerical data available within included reviews and did not involve
    updated searches for primary studies.</p>
  </sec>
  <sec id="review-question-and-eligibility-criteria">
    <title>2.2 Review question and eligibility criteria</title>
    <p>The review question was: What systematic-review evidence is
    available on competitive Paralympic sport science, how is it
    distributed across research domains and sports, and which findings
    are sufficiently direct and methodologically credible to inform
    interpretation and practice?</p>
    <p>Eligible reports were peer-reviewed systematic reviews or
    meta-analyses that described an explicit systematic search and
    study-selection process. Eligible populations included Paralympic
    athletes, competitive Para athletes, or athletes participating in
    IPC-recognized sports. Mixed-population reviews were retained when
    competitive Para-sport evidence was clearly identifiable, separable,
    sufficiently represented, or central to the review question.
    Eligible concepts included athlete health and injury, physiology,
    training, nutrition, recovery, performance assessment,
    classification, biomechanics, technology and equipment,
    sport-specific performance, psychological factors, social support,
    athlete development, and system-level determinants.</p>
    <p>Narrative reviews, scoping reviews, primary studies, editorials,
    conference abstracts, and non-systematic syntheses were excluded.
    Reviews dominated by clinical rehabilitation, general physical
    activity, recreational disability sport, or other non-competitive
    populations were excluded when findings relevant to competitive Para
    sport could not be separately identified or meaningfully
    interpreted.</p>
  </sec>
  <sec id="information-sources-and-search-strategy">
    <title>2.3 Information sources and search strategy</title>
    <p>MEDLINE via PubMed, Embase, Scopus, Web of Science Core
    Collection, SPORTDiscus, and the Cochrane Database of Systematic
    Reviews were searched from inception to 30 June 2026. Database
    searches were conducted between 5 May and 30 June 2026. Search
    concepts combined controlled vocabulary and free-text terms relating
    to Paralympic and Para sport, athletes with eligible impairments,
    and systematic reviews or meta-analyses. Reference lists of included
    reviews were screened, and backward and forward citation tracking
    was performed. No publication-year restriction was applied.
    Eligibility was restricted to full-text peer-reviewed reports
    published in English.</p>
    <p>Complete database-specific strategies, platforms, coverage dates,
    and search information are reported in
    <ext-link ext-link-type="uri" xlink:href="supplementary/supplement-01.html#appendix-s1">Supplementary
    Appendix S1</ext-link>. The search strategy was peer reviewed by an
    experienced information specialist according to PRESS principles.
    Retrieved records were imported into Zotero 7.0 and deduplicated
    using automated duplicate detection followed by manual verification
    of title, authors, year, journal, and DOI.</p>
    <fig id="fig-prisma">
      <caption><p>Figure 1: PRISMA 2020 flow diagram for identification
      and selection of systematic reviews.</p></caption>
      <graphic mimetype="image" mime-subtype="png" xlink:href="media/image3.png"/>
    </fig>
    <fig id="tbl-eligibility">
      <caption><p>Table 1: Eligibility criteria.</p></caption>
      <table-wrap>
        <table>
          <colgroup>
            <col width="33%"/>
            <col width="33%"/>
            <col width="33%"/>
          </colgroup>
          <thead>
            <tr>
              <th align="left"><bold>Criterion</bold></th>
              <th align="left"><bold>Included</bold></th>
              <th align="left"><bold>Excluded</bold></th>
            </tr>
          </thead>
          <tbody>
            <tr>
              <td align="left">Evidence type</td>
              <td align="left">Peer-reviewed systematic reviews and
              meta-analyses with an explicit search and selection
              process</td>
              <td align="left">Narrative/scoping reviews, primary
              studies, editorials, protocols, and conference
              abstracts</td>
            </tr>
            <tr>
              <td align="left">Population</td>
              <td align="left">Paralympic or competitive Para athletes;
              mixed samples only when Para-sport evidence was separable
              or central</td>
              <td align="left">Clinical rehabilitation, general physical
              activity, or non-competitive disability samples without
              separable Para-sport findings</td>
            </tr>
            <tr>
              <td align="left">Concept</td>
              <td align="left">Health, physiology, training, nutrition,
              testing, classification, biomechanics, equipment,
              performance, psychology, social or system factors</td>
              <td align="left">Topics without a direct or interpretable
              link to competitive Para sport</td>
            </tr>
            <tr>
              <td align="left">Publication period</td>
              <td align="left">Database inception to 30 June 2026</td>
              <td align="left">No year restriction</td>
            </tr>
            <tr>
              <td align="left">Language/status</td>
              <td align="left">English; full peer-reviewed report</td>
              <td align="left">Non-English reports without an accessible
              full English translation; non-peer-reviewed or
              abstract-only reports</td>
            </tr>
          </tbody>
        </table>
      </table-wrap>
    </fig>
    <p>Table note: eligibility was applied at the systematic-review
    level; mixed-population reviews were included only when competitive
    Para-sport evidence was separable or central to the review
    question.</p>
  </sec>
  <sec id="study-selection-data-extraction-and-evidence-domains">
    <title>2.4 Study selection, data extraction, and evidence
    domains</title>
    <p>Titles and abstracts and subsequently full texts were screened
    independently by two reviewers against the eligibility criteria.
    Disagreements were resolved by consensus or, when required, by a
    third reviewer. One reviewer extracted data using a piloted
    standardized form, and a second reviewer independently verified all
    extracted fields against the source review. Discrepancies were
    resolved by consensus. Extracted information included bibliographic
    characteristics, review objectives and search dates, populations,
    sports and impairments, primary-study characteristics, outcomes,
    quantitative findings, authors’ conclusions, reported limitations,
    and information relevant to methodological appraisal.</p>
    <p>Each included review was assigned to one primary evidence domain
    according to its principal objective. The domains encompassed injury
    and health; physiological, nutritional, and training determinants;
    performance assessment, testing, and classification; biomechanics,
    equipment, and sport-specific performance; and psychological,
    social, and system-level factors. Cross-domain findings were
    retained narratively but were not counted as independent reviews.
    The complete review corpus is provided in
    <ext-link ext-link-type="uri" xlink:href="supplementary/supplement-01.html#supplementary-table-s1">Supplementary
    Table S1</ext-link>.</p>
  </sec>
  <sec id="risk-of-bias-and-methodological-appraisal">
    <title>2.5 Risk-of-bias and methodological appraisal</title>
    <p>Risk of bias was assessed using ROBIS across all included reviews
    [<xref alt="17" rid="ref-17" ref-type="bibr">17</xref>].
    ROBIS was selected as the principal risk-of-bias framework because
    the corpus included epidemiological, measurement, classification,
    biomechanical, intervention, and broader system-level syntheses.
    AMSTAR 2 was additionally applied to reviews of healthcare,
    training, nutrition, or other interventions falling within its
    intended scope
    [<xref alt="18" rid="ref-18" ref-type="bibr">18</xref>].
    AMSTAR 2 was used to characterize methodological confidence rather
    than to generate a numerical quality score. Two reviewers
    independently completed item-level judgments for both instruments,
    with disagreements resolved through consensus and arbitration by a
    third reviewer when necessary.</p>
    <p>The prespecified critical AMSTAR 2 domains were protocol
    registration before review commencement, adequacy of the literature
    search, justification of excluded studies, appropriate risk-of-bias
    assessment, appropriate meta-analytic methods, consideration of risk
    of bias in interpretation, and assessment of publication bias where
    applicable. Pre-consensus agreement across appraisal judgments was
    89.5% (Cohen’s κ = 0.78). Overall ROBIS and AMSTAR 2 classifications
    are summarized in
    <ext-link ext-link-type="uri" xlink:href="supplementary/supplement-01.html#supplementary-table-s2">Supplementary
    Table S2</ext-link>.</p>
  </sec>
  <sec id="evidence-synthesis-and-management-of-primary-study-overlap">
    <title>2.6 Evidence synthesis and management of primary-study
    overlap</title>
    <p>Evidence was synthesized narratively at review level.
    Quantitative findings were retained only when the outcome,
    denominator, unit, and sport or population context were sufficiently
    clear. Metrics representing different constructs, scales, or
    populations were not pooled or ranked as directly comparable.</p>
    <p>Primary-study overlap was assessed using a citation matrix
    mapping individual primary studies across included reviews.
    Corrected covered area was calculated as CCA = (N - r)/(r × c - r),
    where N is the total number of primary-study occurrences across
    reviews, r is the number of reviews, and c is the number of unique
    primary studies
    [<xref alt="19" rid="ref-19" ref-type="bibr">19</xref>].
    CCA values were interpreted as slight (0-5%), moderate (6-10%), high
    (11-15%), or very high (&gt;15%) overlap. CCA was calculated overall
    and within evidence domains where primary-study identifiers
    permitted reliable matching.</p>
    <p>Overlap was explicitly considered during interpretation. When
    multiple reviews addressed the same question and contained
    substantial shared primary-study evidence, conclusions were not
    given duplicate quantitative weight. Interpretation prioritized the
    more recent, comprehensive, and methodologically credible synthesis,
    whereas older overlapping reviews were retained when they
    contributed unique sport-, impairment-, population-, or
    outcome-specific information. The overlap summary is reported in
    <ext-link ext-link-type="uri" xlink:href="supplementary/supplement-01.html#supplementary-table-s3">Supplementary
    Table S3</ext-link>.</p>
  </sec>
  <sec id="secondary-quantitative-re-analyses-of-injury-and-vo2peak">
    <title>2.7 Secondary quantitative re-analyses of injury and
    VO<sub>2</sub>peak</title>
    <p>Secondary quantitative re-analyses were conducted using numerical
    data reported within two reviews already included in the
    umbrella-review corpus and were not based on updated primary-study
    searches. For injury outcomes, event counts and sample sizes from 31
    prevalence cohorts and reported rates, confidence intervals, and
    injury counts from 21 incidence cohorts were reconstructed from
    Pinheiro et al.
    [<xref alt="8" rid="ref-8" ref-type="bibr">8</xref>].
    For aerobic capacity, 88 absolute and 67 body-mass-normalized
    VO<sub>2</sub>peak source rows were obtained from the official
    supplementary workbook of Baumgart et al.
    [<xref alt="10" rid="ref-10" ref-type="bibr">10</xref>].
    Sport labels were harmonized and VO<sub>2</sub>peak analyses were
    performed separately by sport; no overall cross-sport estimate was
    calculated.</p>
    <p>For injury prevalence, proportions were analyzed on the logit
    scale, with a 0.5 continuity correction applied to boundary
    proportions when required. For incidence, rates were analyzed on the
    log scale. Random-effects models using restricted maximum likelihood
    (REML) with modified Hartung-Knapp (mHK) confidence intervals were
    used for the principal inferential analyses
    [<xref alt="20" rid="ref-20" ref-type="bibr">20</xref>,
    <xref alt="21" rid="ref-21" ref-type="bibr">21</xref>].
    Prediction intervals were calculated using a t distribution with k-2
    degrees of freedom. DerSimonian-Laird (DL) analyses reproducing the
    scales used in the source review were retained as replication
    analyses
    [<xref alt="22" rid="ref-22" ref-type="bibr">22</xref>].
    Source-defined methodological-quality subgroups were examined
    exploratorily, and leave-one-out analyses were used to evaluate
    influence. Subgroup contrasts were descriptive and were not
    interpreted causally.</p>
    <p>For VO<sub>2</sub>peak, the sampling variance of each reported
    mean was calculated as SE² = SD²/n, correcting the use of SD² as
    within-study variance in the source workbook. Random-effects
    analyses were performed separately within each sport using
    DerSimonian-Laird estimation as the corrected primary analysis; REML
    with modified Hartung-Knapp intervals was used as a sensitivity
    analysis where applicable. Sports represented by a single source row
    were reported descriptively, and estimates based on only two rows
    were interpreted cautiously.</p>
    <p>The Baumgart source workbook contained multiple rows from some
    publications, reflecting separately reported samples or subgroups.
    Because independence between all such rows could not always be
    established from the available review-level material, source rows
    were retained as reported and k therefore denotes the number of
    source rows rather than the number of unique publications. This
    potential within-publication dependence was considered when
    interpreting sport-specific estimates.</p>
    <p>Analyses were implemented in Python using versioned datasets and
    NumPy-based random-effects calculations, with figures generated
    using Matplotlib. Input data, executable scripts, transformations,
    variance calculations, confidence- and prediction-interval
    procedures, zero-event handling, sensitivity analyses, leave-one-out
    results, and validation checks will be made available in the
    reproducibility package on the Open Science Framework at release.
    Replication estimates were compared with the source reviews as a
    data-integrity check.</p>
  </sec>
</sec>
<sec id="results">
  <title>3. Results</title>
  <sec id="general-characteristics">
    <title>3.1 General characteristics</title>
    <p>Thirty-eight systematic reviews published between 2012 and 2026
    were included, 32 of which were published from 2021 onward. The
    evidence base comprised injury and health (n=9), physiological,
    nutritional, and training determinants (n=8), performance
    assessment, testing, and classification (n=9), biomechanics,
    equipment, and sport-specific performance (n=7), and psychological,
    social, and system-level factors (n=5). The search identified 2,846
    records; 912 duplicates were removed, 1,934 records were screened,
    and 181 full-text reports were assessed. Of these, 143 were excluded
    and 38 systematic reviews were included. Reasons for full-text
    exclusion were failure to meet the systematic-review definition
    (n=57), ineligible or non-separable Para-sport populations (n=36),
    topics not directly relevant to competitive Para sport (n=27),
    ineligible publication status (n=13), unavailable full text (n=5),
    and duplicate, companion, or updated reports (n=5) (Figure 1).</p>
    <p>Coverage across sports was uneven. Wheelchair basketball,
    wheelchair rugby, wheelchair tennis, wheelchair racing, and other
    seated sports were represented across multiple evidence domains,
    whereas blind football, goalball, Para swimming, Para powerlifting,
    Boccia, seated throwing, and running with brain impairment were
    represented by more focused review-level evidence. Several
    Paralympic disciplines were absent or represented only indirectly in
    broader multi-sport reviews.</p>
    <fig id="fig-evidence-domains">
      <caption><p>Figure 2: Distribution across evidence domains and
      publication chronology of the 38 included systematic
      reviews.</p></caption>
      <graphic mimetype="image" mime-subtype="svg+xml" xlink:href="media/image5.svg"/>
    </fig>
    <p>Source: included-review corpus (Supplementary Table S1).</p>
    <fig id="tbl-domain-summary">
      <caption><p>Table 2: Domain-level evidence summary.</p></caption>
      <table-wrap>
        <table>
          <colgroup>
            <col width="25%"/>
            <col width="25%"/>
            <col width="25%"/>
            <col width="25%"/>
          </colgroup>
          <thead>
            <tr>
              <th><bold>Domain</bold></th>
              <th><bold>n</bold></th>
              <th><bold>Main contexts</bold></th>
              <th><bold>Synthesis</bold></th>
            </tr>
          </thead>
          <tbody>
            <tr>
              <td>Injury and health</td>
              <td>9</td>
              <td>Wheelchair basketball, sitting volleyball, mixed Para
              sport, wheelchair athletes, eye illness, concussion</td>
              <td>Upper-limb and shoulder burden recurred across
              wheelchair and sitting sports; injury definitions and
              denominators varied.</td>
            </tr>
            <tr>
              <td>Physiology, nutrition, and training</td>
              <td>8</td>
              <td>Sitting sports, Para swimming, blind football,
              goalball, supplementation, sleep, elite wheelchair
              sport</td>
              <td>Physiological profiles were sport- and
              impairment-sensitive; intervention evidence for nutrition,
              recovery, and training was sparse or inconsistent.</td>
            </tr>
            <tr>
              <td>Testing and classification</td>
              <td>9</td>
              <td>Wheelchair court sports, cross-sport classification,
              muscle strength, isokinetic and field testing</td>
              <td>Many tools showed acceptable reliability, but
              validity, responsiveness, class-specific interpretation,
              and standardization were inconsistent.</td>
            </tr>
            <tr>
              <td>Biomechanics and equipment</td>
              <td>7</td>
              <td>Wheelchair free throw, running with brain impairment,
              Boccia, blind football, Para powerlifting, seated throws,
              assistive technology</td>
              <td>Performance determinants were highly task-specific and
              often depended on impairment, sport class, and
              athlete-equipment interaction.</td>
            </tr>
            <tr>
              <td>Psychological and system-level</td>
              <td>5</td>
              <td>Burnout, coping, psychosocial characteristics,
              well-being, social support, training systems, sport
              development</td>
              <td>Evidence identified psychological, social, coaching,
              accessibility, financial, and system-level determinants,
              but was often cross-sectional, qualitative, or based on
              broader disability-sport populations.</td>
            </tr>
          </tbody>
        </table>
      </table-wrap>
    </fig>
  </sec>
  <sec id="injury-and-health">
    <title>3.2 Injury and health</title>
    <p>Nine reviews addressed injury, musculoskeletal complaints,
    sport-related health problems, concussion, and eye illness
    [<xref alt="23" rid="ref-23" ref-type="bibr">23</xref>].
    Pinheiro et al.
    [<xref alt="8" rid="ref-8" ref-type="bibr">8</xref>]
    reported a pooled musculoskeletal-injury prevalence of 40.8% (95% CI
    32.5-49.8) and an incidence of 14.3 injuries per 1,000 athlete-days.
    Heterogeneity was high, and the estimates combined sports and
    impairment groups with different exposure patterns.</p>
    <p>Upper-limb involvement recurred across sport-specific reviews. In
    wheelchair basketball, Sá et al.
    [<xref alt="24" rid="ref-24" ref-type="bibr">24</xref>]
    synthesized eight studies including 753 players; 36.4% were reported
    as injured, 47.2% of injuries involved the upper limb, and the
    shoulder accounted for approximately 22%. In sitting volleyball,
    Moraes et al.
    [<xref alt="25" rid="ref-25" ref-type="bibr">25</xref>]
    reported an injury prevalence of 54.1%, with 53.8% of injuries
    affecting the upper limb and 28.9% the shoulder. Overuse injuries
    were more frequent than acute trauma, and approximately half
    resulted in time loss.</p>
    <p>Among wheelchair athletes, shoulder complaints ranged from 16% to
    76% across studies using different definitions, recall periods, and
    populations
    [<xref alt="26" rid="ref-26" ref-type="bibr">26</xref>].
    Jodar-Boixet et al.
    [<xref alt="27" rid="ref-27" ref-type="bibr">27</xref>]
    reported Wheelchair User’s Shoulder Pain Index reliability
    coefficients of 0.84-0.99 and a correlation of r=0.90 with a visual
    analogue scale, while evidence for several other measurement
    properties remained limited or indeterminate.</p>
    <p>Concussion and eye-illness reviews also showed sport- and
    impairment-specific variation. Singh et al.
    [<xref alt="28" rid="ref-28" ref-type="bibr">28</xref>]
    reported higher concussion incidence in selected contexts, including
    Para ice hockey and athletes with visual impairment. Kunorozva et
    al.
    [<xref alt="29" rid="ref-29" ref-type="bibr">29</xref>]
    reported eye-illness incidence of approximately 1.6-2.2 per 1,000
    athlete-days in winter settings and 0.3-0.5 per 1,000 athlete-days
    in summer settings.</p>
  </sec>
  <sec id="physiological-nutritional-and-training-determinants">
    <title>3.3 Physiological, nutritional, and training
    determinants</title>
    <p>Eight reviews addressed aerobic capacity, swimming physiology,
    anthropometry and body composition, balance, sleep, dietary
    supplementation, and training-related interventions. Baumgart et al.
    [<xref alt="10" rid="ref-10" ref-type="bibr">10</xref>]
    included 57 studies and 771 athletes across 14 Paralympic
    sitting-sport disciplines. Aerobic capacity varied markedly across
    sports, with higher values generally reported in endurance-oriented
    disciplines such as Nordic sit skiing and handcycling than in
    shooting, wheelchair rugby, and some court-sport samples. Reported
    values also varied according to sex, impairment, test mode, training
    status, and whether oxygen uptake was expressed absolutely or
    relative to body mass.</p>
    <p>Feitosa et al.
    [<xref alt="11" rid="ref-11" ref-type="bibr">11</xref>]
    included ten studies involving 142 swimmers with physical
    impairments. Oxygen uptake, blood lactate, and heart rate were
    assessed using heterogeneous protocols; swimmers with lower
    functional impact of impairment generally showed higher
    oxygen-uptake and lactate responses than those with greater
    impairment impact.</p>
    <p>Evidence concerning supplementation was limited. Shaw et al.
    [<xref alt="30" rid="ref-30" ref-type="bibr">30</xref>]
    included 15 studies and 311 participants across seven supplement
    categories. Caffeine was the most frequently examined supplement,
    but effects differed across sprint, time-trial, power, and
    perceptual outcomes. Perret and Flueck
    [<xref alt="31" rid="ref-31" ref-type="bibr">31</xref>]
    similarly identified few controlled studies in athletes with spinal
    cord injury.</p>
    <p>Sport-specific reviews reported position-related differences in
    body mass and body fat in blind football
    [<xref alt="32" rid="ref-32" ref-type="bibr">32</xref>],
    heterogeneous balance findings in goalball
    [<xref alt="33" rid="ref-33" ref-type="bibr">33</xref>],
    frequent poor sleep quality and limited impairment-specific
    adaptation of sleep measures
    [<xref alt="34" rid="ref-34" ref-type="bibr">34</xref>],
    and variable effects of cooling, respiratory training, nutrition,
    and equipment adaptations in elite wheelchair sport
    [<xref alt="35" rid="ref-35" ref-type="bibr">35</xref>].</p>
  </sec>
  <sec id="performance-assessment-testing-and-classification">
    <title>3.4 Performance assessment, testing, and
    classification</title>
    <p>Nine reviews examined impairment measures, field and laboratory
    tests, ball-handling skills, muscle strength, mobility performance,
    and evidence-based classification
    [<xref alt="36" rid="ref-36" ref-type="bibr">36</xref>].
    Wileman et al.
    [<xref alt="7" rid="ref-7" ref-type="bibr">7</xref>]
    synthesized 51 articles and Hutchinson et al.
    [<xref alt="6" rid="ref-6" ref-type="bibr">6</xref>]
    23 studies; both identified comparatively stronger evidence for
    reliability than for relationships between impairment measures and
    sport-specific performance or activity limitation.</p>
    <p>In wheelchair sport, Ferreira da Silva et al.
    [<xref alt="37" rid="ref-37" ref-type="bibr">37</xref>]
    identified passing and sprinting among the most frequently assessed
    skills, whereas Altmann et al.
    [<xref alt="38" rid="ref-38" ref-type="bibr">38</xref>]
    reported stronger measurement evidence for maximal throwing distance
    and velocity than for throwing accuracy or catching. Luarte et al.
    [<xref alt="39" rid="ref-39" ref-type="bibr">39</xref>]
    documented frequent use of sprint, passing, handgrip, agility,
    Wingate, and dribbling tests in elite wheelchair basketball.</p>
    <p>Gavel et al.
    [<xref alt="12" rid="ref-12" ref-type="bibr">12</xref>]
    identified 45 mobility field tests across 21 studies and 317
    participants in wheelchair rugby, basketball, and tennis.
    Thirty-five tests were anaerobic and ten aerobic; reliability ranged
    from moderate to excellent (ICC 0.62-0.99), whereas validity
    evidence was more limited. O’Connor et al.
    [<xref alt="13" rid="ref-13" ref-type="bibr">13</xref>]
    included 30 observational studies of muscle-strength assessment; 76%
    involved wheelchair sports, 53% used isometric testing, 33%
    isokinetic testing, and only five studies reported reliability data
    [<xref alt="40" rid="ref-40" ref-type="bibr">40</xref>].</p>
    <p>Across classification reviews, evidence was more developed for
    measurement reliability than for validity linking impairment
    measures to sport-specific activity limitation, particularly within
    class-specific samples.</p>
  </sec>
  <sec id="biomechanics-equipment-and-sport-specific-performance">
    <title>3.5 Biomechanics, equipment, and sport-specific
    performance</title>
    <p>Seven reviews synthesized sport-specific biomechanical,
    equipment, and performance evidence. In wheelchair basketball, de
    Oliveira Silva et al.
    [<xref alt="41" rid="ref-41" ref-type="bibr">41</xref>]
    included seven cross-sectional studies and 216 male players.
    Lower-class athletes generally showed lower release heights and
    higher release speeds, whereas higher-class players exhibited more
    sequential throwing patterns; shooting accuracy did not differ
    consistently by class.</p>
    <p>Fiorese et al.
    [<xref alt="42" rid="ref-42" ref-type="bibr">42</xref>]
    included eight studies and 100 runners with brain impairment and
    reported differences in step organization, horizontal propulsion,
    flight time, and joint-level work compared with non-disabled
    runners.</p>
    <p>Reviews of Boccia and blind football described multidimensional
    performance determinants spanning throwing mechanics, postural
    stability, dexterity, coordination, aerobic fitness, match demands,
    technical-tactical actions, balance, recovery, and training
    [<xref alt="43" rid="ref-43" ref-type="bibr">43</xref>,
    <xref alt="44" rid="ref-44" ref-type="bibr">44</xref>].</p>
    <p>In Para powerlifting, Oliveira et al.
    [<xref alt="45" rid="ref-45" ref-type="bibr">45</xref>]
    identified maximal strength, bar velocity, grip width, range of
    motion, technique, and fatigue monitoring as recurrent performance
    variables. Garcia-Carrillo et al.
    [<xref alt="46" rid="ref-46" ref-type="bibr">46</xref>]
    highlighted release velocity, release angle, trunk and grip
    strength, and throwing-frame configuration in adapted throws. Liu et
    al. [<xref alt="2" rid="ref-2" ref-type="bibr">2</xref>]
    included 42 studies of assistive technologies involving prostheses,
    wheelchairs, seated devices, sensors, and digital tools, with
    reported effects varying according to device configuration,
    impairment, sport, and task.</p>
  </sec>
  <sec id="psychological-social-and-system-level-factors">
    <title>3.6 Psychological, social, and system-level factors</title>
    <p>Five reviews addressed psychological, social,
    training-environment, and sport-system factors. Ferreira et al.
    [<xref alt="47" rid="ref-47" ref-type="bibr">47</xref>]
    included eight studies and 588 athletes with disabilities; five
    studies examined coping and three burnout. Burnout was associated
    with socially prescribed perfectionism and sleep, while coping was
    associated with motivation, engagement, anxiety, depression, and
    performance-related variables. Most evidence was
    cross-sectional.</p>
    <p>Jefferies et al.
    [<xref alt="48" rid="ref-48" ref-type="bibr">48</xref>]
    synthesized 16 psychosocial studies addressing motivation, imagery,
    stress and coping, personality, attitudes toward disability, and
    retirement transition. Mira et al.
    [<xref alt="14" rid="ref-14" ref-type="bibr">14</xref>]
    included 27 studies and reported associations between sport
    participation and well-being, resilience, quality of life,
    self-esteem, and social support, although several samples extended
    beyond elite Paralympic sport.</p>
    <p>Rodríguez Macías et al.
    [<xref alt="1" rid="ref-1" ref-type="bibr">1</xref>]
    identified coaching, family support, motivation, accessibility,
    finance, and infrastructure as determinants within the Para-athlete
    training process. Fadian et al.
    [<xref alt="3" rid="ref-3" ref-type="bibr">3</xref>]
    similarly identified funding, infrastructure, policy, coaching,
    technology, and national-system characteristics in broader analyses
    of Paralympic sport development.</p>
  </sec>
  <sec id="methodological-credibility-overlap-and-selected-quantitative-findings">
    <title>3.7 Methodological credibility, overlap, and selected
    quantitative findings</title>
    <p>ROBIS classified 11 reviews as low risk of bias, 23 as high risk,
    and 4 as unclear. Among the 10 reviews for which AMSTAR 2 was
    applicable, methodological confidence was moderate in 2, low in 3,
    and critically low in 5; no review achieved high confidence. Overall
    corrected covered area was 7.6%, corresponding to moderate
    primary-study overlap. The greatest overlap occurred in injury and
    health and in performance assessment, testing, and classification.
    Table 3 summarizes numerical findings from individual reviews for
    which outcomes, denominators, units, and population context were
    sufficiently clear; these estimates were retained descriptively
    rather than treated as directly comparable effect estimates.</p>
    <fig id="tbl-quantitative-findings">
      <caption><p>Table 3: Selected quantitative findings retained from
      included reviews.</p></caption>
      <table-wrap>
        <table>
          <colgroup>
            <col width="20%"/>
            <col width="20%"/>
            <col width="20%"/>
            <col width="20%"/>
            <col width="20%"/>
          </colgroup>
          <thead>
            <tr>
              <th><bold>Context</bold></th>
              <th><bold>Outcome</bold></th>
              <th><bold>Estimate</bold></th>
              <th><bold>Review</bold></th>
              <th><bold>Interpretation</bold></th>
            </tr>
          </thead>
          <tbody>
            <tr>
              <td>Mixed Para sport</td>
              <td>Musculoskeletal injury prevalence</td>
              <td>40.8% (95% CI 32.5-49.8)</td>
              <td>[<xref alt="8" rid="ref-8" ref-type="bibr">8</xref>]</td>
              <td>Pooled across heterogeneous sports and
              impairments</td>
            </tr>
            <tr>
              <td>Mixed Para sport</td>
              <td>Musculoskeletal injury incidence</td>
              <td>14.3 per 1,000 athlete-days</td>
              <td>[<xref alt="8" rid="ref-8" ref-type="bibr">8</xref>]</td>
              <td>Exposure definitions varied</td>
            </tr>
            <tr>
              <td>Wheelchair basketball</td>
              <td>Players reported as injured</td>
              <td>36.4% (274/753)</td>
              <td>[<xref alt="24" rid="ref-24" ref-type="bibr">24</xref>]</td>
              <td>Eight primary studies</td>
            </tr>
            <tr>
              <td>Wheelchair basketball</td>
              <td>Upper-limb share of injuries</td>
              <td>47.2%</td>
              <td>[<xref alt="24" rid="ref-24" ref-type="bibr">24</xref>]</td>
              <td>Shoulder approximately 22%</td>
            </tr>
            <tr>
              <td>Sitting volleyball</td>
              <td>Injury prevalence</td>
              <td>54.1%</td>
              <td>[<xref alt="25" rid="ref-25" ref-type="bibr">25</xref>]</td>
              <td>Upper limb 53.8%; shoulder 28.9%</td>
            </tr>
            <tr>
              <td>Wheelchair athletes</td>
              <td>Shoulder complaints</td>
              <td>16%-76%</td>
              <td>[<xref alt="26" rid="ref-26" ref-type="bibr">26</xref>]</td>
              <td>Range reflects heterogeneous definitions</td>
            </tr>
            <tr>
              <td>Para athletes</td>
              <td>WUSPI reliability</td>
              <td>0.84-0.99</td>
              <td>[<xref alt="27" rid="ref-27" ref-type="bibr">27</xref>]</td>
              <td>High correlation with VAS, r=0.90</td>
            </tr>
            <tr>
              <td>Sitting sports</td>
              <td>Athletes in VO<sub>2</sub>peak review</td>
              <td>57 studies; 771 athletes</td>
              <td>[<xref alt="10" rid="ref-10" ref-type="bibr">10</xref>]</td>
              <td>14 sitting-sport disciplines; large between-sport
              variation</td>
            </tr>
            <tr>
              <td>Wheelchair court sports</td>
              <td>Mobility-test reliability</td>
              <td>ICC 0.62-0.99</td>
              <td>[<xref alt="12" rid="ref-12" ref-type="bibr">12</xref>]</td>
              <td>Validity evidence remained limited</td>
            </tr>
            <tr>
              <td>Blind football</td>
              <td>Studies and players in body-composition review</td>
              <td>10 studies; 168 players</td>
              <td>[<xref alt="32" rid="ref-32" ref-type="bibr">32</xref>]</td>
              <td>Position-specific differences reported</td>
            </tr>
          </tbody>
        </table>
      </table-wrap>
    </fig>
    <p>Abbreviations: CI, confidence interval; ICC, intraclass
    correlation coefficient; VAS, visual analogue scale;
    VO<sub>2</sub>peak, peak oxygen uptake; WUSPI, Wheelchair User’s
    Shoulder Pain Index.</p>
  </sec>
  <sec id="secondary-quantitative-re-analyses-of-injury-and-vo2peak-1">
    <title>3.8 Secondary quantitative re-analyses of injury and
    VO<sub>2</sub>peak</title>
    <p>The primary REML+mHK analysis of 31 prevalence cohorts yielded a
    pooled prevalence of 41.9% (95% CI 29.8-55.0), with a 95% prediction
    interval of 4.1-92.3%. The DL replication estimate was 40.7% (95% CI
    32.4-49.6; I²=97.7%), closely reproducing the 40.8% estimate
    reported in the source review. The corresponding DL prediction
    interval was 8.4-83.7%. Leave-one-out DL estimates ranged from 39.1%
    to 43.2%. In source-defined methodological-quality subgroups, pooled
    prevalence was 34.6% in the higher-quality group and 47.2% in the
    lower-quality group.</p>
    <p>Across 21 incidence cohorts, the primary REML+mHK analysis
    yielded 13.4 injuries per 1,000 athlete-days (95% CI 7.0-25.4), with
    a 95% prediction interval of 0.66-269.2. The DL replication estimate
    was 14.4 per 1,000 athlete-days (95% CI 12.0-16.8; I²=98.4%),
    compared with 14.3 in the source review; its prediction interval was
    3.7-25.1. Leave-one-out replication estimates ranged from 11.9 to
    15.9 per 1,000 athlete-days. Source-defined higher- and
    lower-quality subgroup estimates were 11.7 and 23.2 per 1,000
    athlete-days, respectively.</p>
    <p>The VO<sub>2</sub>peak dataset comprised 88 absolute and 67
    body-mass-normalized source rows across 14 sitting-sport categories.
    Sport-specific normalized estimates ranged from 17.4 mL/kg/min in
    shooting (k=2) to 45.3 mL/kg/min in Nordic sit skiing (k=3).
    Selected estimates were 20.6 mL/kg/min for wheelchair rugby (k=11),
    34.2 for wheelchair basketball (k=15), 35.9 for handcycling (k=4),
    and 40.3 for wheelchair racing (k=16). Corresponding absolute
    estimates for shooting, wheelchair rugby, wheelchair basketball,
    handcycling, wheelchair racing, and Nordic sit skiing were 1.44,
    1.43, 2.46, 2.57, 2.21, and 2.87 L/min, respectively. Between-row
    heterogeneity was substantial in most multi-row sport categories.
    Because some publications contributed multiple source rows, k
    represents source rows rather than unique publications. Single-row
    categories were reported descriptively, and k=2 estimates were
    interpreted cautiously.</p>
    <fig id="tbl-secondary-reanalysis">
      <caption><p>Table 4: Secondary quantitative re-analysis
      summary.</p></caption>
      <table-wrap>
        <table>
          <colgroup>
            <col width="17%"/>
            <col width="17%"/>
            <col width="17%"/>
            <col width="17%"/>
            <col width="17%"/>
            <col width="17%"/>
          </colgroup>
          <thead>
            <tr>
              <th><bold>Outcome / scale</bold></th>
              <th><bold>Sport or subgroup</bold></th>
              <th><bold>k</bold></th>
              <th align="left"><bold>Primary estimate (95%
              CI)</bold></th>
              <th align="left"><bold>I²</bold></th>
              <th align="left"><bold>Sensitivity /
              interpretation</bold></th>
            </tr>
          </thead>
          <tbody>
            <tr>
              <td>Injury prevalence</td>
              <td>All cohorts</td>
              <td>31</td>
              <td align="left">41.9% (29.8-55.0)</td>
              <td align="left">97.7% in DL replication</td>
              <td align="left">REML+mHK primary; PI 4.1-92.3%. DL
              replication 40.7% (32.4-49.6)</td>
            </tr>
            <tr>
              <td>Injury prevalence</td>
              <td>Source-defined higher vs lower quality</td>
              <td>14 / 17</td>
              <td align="left">34.6% vs 47.2%</td>
              <td align="left">98.2% / 95.8%</td>
              <td align="left">Exploratory subgroup contrast</td>
            </tr>
            <tr>
              <td>Injury incidence</td>
              <td>All cohorts</td>
              <td>21</td>
              <td align="left">13.4 (7.0-25.4) per 1,000
              athlete-days</td>
              <td align="left">98.4% in DL replication</td>
              <td align="left">Log-rate REML+mHK primary; PI 0.66-269.2.
              DL replication 14.4 (12.0-16.8)</td>
            </tr>
            <tr>
              <td>Injury incidence</td>
              <td>Source-defined higher vs lower quality</td>
              <td>11 / 10</td>
              <td align="left">11.7 vs 23.2 per 1,000 athlete-days</td>
              <td align="left">98.6% / 98.3%</td>
              <td align="left">Exploratory subgroup contrast</td>
            </tr>
            <tr>
              <td>Normalized VO<sub>2</sub>peak</td>
              <td>Shooting</td>
              <td>2</td>
              <td align="left">17.4 (15.1–19.7) mL/kg/min</td>
              <td align="left">0.0%</td>
              <td align="left">Sparse; k=2 estimate interpreted
              cautiously</td>
            </tr>
            <tr>
              <td>Normalized VO<sub>2</sub>peak</td>
              <td>Wheelchair rugby</td>
              <td>11</td>
              <td align="left">20.6 (17.7–23.5) mL/kg/min</td>
              <td align="left">91.2%</td>
              <td align="left">Sport-specific pooling only</td>
            </tr>
            <tr>
              <td>Normalized VO<sub>2</sub>peak</td>
              <td>Wheelchair basketball</td>
              <td>15</td>
              <td align="left">34.2 (32.1–36.2) mL/kg/min</td>
              <td align="left">79.9%</td>
              <td align="left">Sport-specific pooling only</td>
            </tr>
            <tr>
              <td>Normalized VO<sub>2</sub>peak</td>
              <td>Handcycling</td>
              <td>4</td>
              <td align="left">35.9 (31.5–40.4) mL/kg/min</td>
              <td align="left">67.5%</td>
              <td align="left">Sport-specific pooling only</td>
            </tr>
            <tr>
              <td>Normalized VO<sub>2</sub>peak</td>
              <td>Wheelchair racing</td>
              <td>16</td>
              <td align="left">40.3 (37.7–42.8) mL/kg/min</td>
              <td align="left">74.1%</td>
              <td align="left">Sport-specific pooling only</td>
            </tr>
            <tr>
              <td>Normalized VO<sub>2</sub>peak</td>
              <td>Nordic sit skiing</td>
              <td>3</td>
              <td align="left">45.3 (37.6–53.0) mL/kg/min</td>
              <td align="left">74.7%</td>
              <td align="left">Sport-specific pooling only</td>
            </tr>
          </tbody>
        </table>
      </table-wrap>
    </fig>
    <p>Table note: REML with modified Hartung-Knapp confidence intervals
    is primary for injury outcomes; DerSimonian-Laird estimates are
    replication analyses. VO<sub>2</sub>peak values are corrected
    DerSimonian-Laird estimates using SE² and are pooled only within
    sport. DL, DerSimonian-Laird; mHK, modified Hartung-Knapp; PI,
    prediction interval; REML, restricted maximum likelihood.</p>
    <fig id="fig-injury-prevalence">
      <caption><p>Figure 3: Forest plot of injury prevalence. Study
      estimates use Wilson confidence intervals; square area is
      proportional to random-effects weight. Colors distinguish the
      source-defined higher- and lower-methodological-quality groups
      reported in the source review; diamonds show the DerSimonian-Laird
      replication estimate and the primary REML+mHK
      estimate.</p></caption>
      <graphic mimetype="image" mime-subtype="svg+xml" xlink:href="media/image7.svg"/>
    </fig>
    <fig id="fig-injury-incidence">
      <caption><p>Figure 4: Forest plot of injury incidence per 1,000
      athlete-days. The x-axis is logarithmic; study confidence
      intervals are those reported in the source review, and square area
      is proportional to random-effects weight. Source-defined
      methodological-quality groups are shown. Diamonds show the
      DerSimonian-Laird replication estimate and the primary REML+mHK
      estimate. A reported zero lower bound is displayed at 0.1 only for
      plotting.</p></caption>
      <graphic mimetype="image" mime-subtype="svg+xml" xlink:href="media/image9.svg"/>
    </fig>
    <fig id="fig-vo2peak">
      <caption><p>Figure 5: Sport-specific absolute and
      body-mass-normalized VO<sub>2</sub>peak reanalysis using the
      sampling variance of each study mean (SE²). Sports were not pooled
      together.</p></caption>
      <graphic mimetype="image" mime-subtype="svg+xml" xlink:href="media/image11.svg"/>
    </fig>
  </sec>
  <sec id="cross-cutting-evidence-gaps">
    <title>3.9 Cross-cutting evidence gaps</title>
    <p>Four recurring evidence gaps were identified across domains.
    First, reviews frequently combined athletes differing in sport,
    impairment, class, competitive level, and equipment configuration
    without reporting sufficiently detailed subgroup data. Second, women
    and athletes with intellectual impairment were underrepresented, and
    sex-specific analyses were uncommon. Third, heterogeneity in test
    protocols, case definitions, outcome measures, and exposure
    denominators frequently limited comparison across studies and
    reviews. Fourth, many primary studies were small, cross-sectional,
    single-center investigations with limited longitudinal follow-up or
    linkage to classification and performance outcomes
    [<xref alt="7" rid="ref-7" ref-type="bibr">7</xref>,
    <xref alt="9" rid="ref-9" ref-type="bibr">9</xref>,
    <xref alt="13" rid="ref-13" ref-type="bibr">13</xref>,
    <xref alt="14" rid="ref-14" ref-type="bibr">14</xref>].</p>
  </sec>
</sec>
<sec id="discussion">
  <title>4. Discussion</title>
  <sec id="principal-findings">
    <title>4.1 Principal findings</title>
    <p>This umbrella review provides a broad synthesis of the current
    systematic-review evidence across Paralympic sport science.
    Thirty-eight reviews were identified across athlete health,
    physiology and training, performance assessment and classification,
    biomechanics and technology, and psychological and system-level
    domains. The evidence base has expanded substantially, but its
    distribution remains uneven, with wheelchair and seated sports more
    consistently represented than many ambulatory disciplines and other
    Paralympic populations.</p>
    <p>The most important finding is that the available evidence is
    broad but not uniformly mature. Methodological appraisal was
    predominantly unfavorable, with most reviews rated at high risk of
    bias by ROBIS and most AMSTAR 2-applicable reviews showing low or
    critically low confidence. Corrected covered area also indicated
    moderate primary-study overlap, particularly within injury and
    health and performance assessment/testing/classification. Thus, the
    apparent volume of review-level literature should not be interpreted
    as an equivalent volume of independent primary evidence. Across
    domains, sport, impairment, class, equipment, sex, exposure
    definition, and testing protocol repeatedly influenced the
    interpretation of findings. The secondary analyses reinforced this
    context dependence through very wide injury prediction intervals and
    marked between-sport variation in VO<sub>2</sub>peak.</p>
  </sec>
  <sec id="athlete-health-substantial-burden-and-limited-generalizability">
    <title>4.2 Athlete health: substantial burden and limited
    generalizability</title>
    <p>The injury literature consistently indicates that musculoskeletal
    health is an important concern in Para sport, but the magnitude of
    risk varies considerably across sports and surveillance settings.
    The secondary re-analysis produced a prevalence estimate of 41.9%
    and an incidence estimate of 13.4 injuries per 1,000 athlete-days,
    yet both were accompanied by very wide prediction intervals. The
    pooled estimate summarizes the average of the available evidence,
    whereas the prediction interval reflects the range of values that
    may plausibly be observed in a new setting. In this context, a
    single pooled rate has limited value as a universal Para-sport
    benchmark.</p>
    <p>Despite this heterogeneity, upper-limb and shoulder problems
    recurred in wheelchair basketball, sitting volleyball, and broader
    wheelchair-athlete populations. This pattern is compatible with
    repeated sport-specific and daily upper-limb loading, although
    causal attribution cannot be made from the review-level evidence
    alone. Differences in injury definitions, exposure denominators,
    follow-up duration, and inclusion of non-time-loss health problems
    also contributed materially to between-study variation. Recent
    prospective studies cited here as contextual evidence, rather than
    as part of the umbrella corpus, similarly show that health problems
    fluctuate across training and competition and that non-time-loss
    conditions may contribute substantially to total burden
    [<xref alt="49" rid="ref-49" ref-type="bibr">49</xref>,
    <xref alt="50" rid="ref-50" ref-type="bibr">50</xref>]. More
    standardized prospective surveillance and consistent reporting of
    burden, exposure, and severity would improve comparability across
    Para-sport settings
    [<xref alt="51" rid="ref-51" ref-type="bibr">51</xref>,
    <xref alt="52" rid="ref-52" ref-type="bibr">52</xref>].</p>
  </sec>
  <sec id="physiology-and-training-context-dependent-physiological-evidence">
    <title>4.3 Physiology and training: context-dependent physiological
    evidence</title>
    <p>The physiological evidence reinforces the limited value of broad
    cross-sport benchmarking. Cardiorespiratory responses and aerobic
    capacity varied substantially across Para-sport disciplines, and the
    VO<sub>2</sub>peak re-analysis quantitatively illustrates this
    heterogeneity. Absolute and body-mass-normalized VO<sub>2</sub>peak
    values answer different questions, while impairment, sex, active
    muscle mass, autonomic function, test modality, ergometer
    configuration, training status, and sport technique may all
    influence observed values. The differences between shooting,
    wheelchair rugby, wheelchair basketball, handcycling, wheelchair
    racing, and Nordic sit skiing should therefore be interpreted within
    their sport and functional contexts rather than as a ranking of
    overall fitness.</p>
    <p>The broader training, nutrition, recovery, and sleep literature
    was comparatively sparse and heterogeneous. Controlled studies were
    limited, samples were often small, and impairment-specific evidence
    was uneven. Accordingly, the current literature provides stronger
    support for sport- and impairment-specific interpretation than for
    universal Para-sport physiological reference standards or broad
    intervention recommendations. Future studies should report the
    testing configuration and athlete characteristics needed to
    determine whether observed differences reflect sport demands,
    impairment-related physiology, or methodological variation.</p>
  </sec>
  <sec id="performance-assessment-and-classification-reliability-is-not-sufficient">
    <title>4.4 Performance assessment and classification: reliability is
    not sufficient</title>
    <p>The testing literature shows a consistent imbalance between
    evidence for reliability and evidence for validity or decision
    relevance. Across mobility, sprint, throwing, passing, and strength
    assessments, many tools showed moderate-to-excellent reliability,
    whereas evidence for criterion validity, responsiveness, and
    class-specific interpretation was less developed. Reliability is
    necessary for measurement, but reproducibility alone does not
    establish that a test measures the construct relevant to
    performance, detects meaningful change, or supports a specific
    classification decision.</p>
    <p>This distinction is particularly important for classification.
    Evidence-based classification requires not only a reliable measure
    of eligible impairment but also evidence that the impairment
    produces a meaningful limitation in the activities that determine
    performance in that sport. A performance test may be affected by
    impairment, training, technique, motivation, or equipment
    simultaneously and therefore cannot automatically be interpreted as
    a pure impairment measure. Future research should place greater
    emphasis on validity, responsiveness, class-specific interpretation,
    and explicit separation of impairment effects from other
    determinants of performance.</p>
  </sec>
  <sec id="biomechanics-and-assistive-technology-athlete-equipment-task-interactions">
    <title>4.5 Biomechanics and assistive technology:
    athlete-equipment-task interactions</title>
    <p>Biomechanical and equipment-related findings were among the most
    sport-specific in the review. Across wheelchair basketball, adapted
    throwing, running with brain impairment, Boccia, Para powerlifting,
    and assistive-technology studies, performance outcomes depended on
    the interaction between functional capacity, task demands, and
    equipment configuration. In wheelchair basketball, for example,
    class-related differences in release height, release speed, and
    sequencing were not accompanied by consistent differences in
    shooting accuracy, indicating that different movement solutions may
    coexist within the same performance task.</p>
    <p>These findings highlight the importance of treating equipment as
    part of the experimental condition rather than as a background
    characteristic. Wheelchair geometry, seating, prosthetic components,
    throwing frames, grips, and other relevant interfaces can alter
    movement mechanics and loading and should be reported in sufficient
    detail to support interpretation and replication. More broadly,
    biomechanical findings in Para sport are most informative when they
    are considered within the athlete-equipment-task context in which
    they were generated.</p>
  </sec>
  <sec id="psychological-and-system-level-evidence">
    <title>4.6 Psychological and system-level evidence</title>
    <p>The psychological and system-level literature broadens the
    evidence base beyond physiological and mechanical determinants.
    Reviews identified associations involving burnout, coping,
    motivation, resilience, social support, coaching, accessibility,
    finance, infrastructure, technology, and broader sport-system
    characteristics. These findings indicate that training continuity
    and performance development are embedded within organizational and
    social environments as well as within the athlete.</p>
    <p>This domain was also among the least direct with respect to
    high-performance outcomes. Much of the evidence was cross-sectional,
    qualitative, or derived from broader disability-sport populations
    rather than narrowly defined competitive Paralympic cohorts, which
    limits causal interpretation. Future studies should increasingly use
    longitudinal designs and link psychological and system-level
    determinants to clearly defined health, training, and performance
    outcomes in sport-specific Para-athlete populations.</p>
  </sec>
  <sec id="structural-heterogeneity-and-interpretation">
    <title>4.7 Structural heterogeneity and interpretation</title>
    <p>One of the most important interpretive findings is that
    heterogeneity in Paralympic sport science is not purely statistical.
    Some variation reflects methodological inconsistency and should be
    reduced through better standardization, including inconsistent
    injury definitions, exposure denominators, and testing protocols.
    Other variation reflects genuine differences in impairment, class,
    sex, active muscle mass, equipment, sport rules, competitive level,
    and task demands and should instead be investigated as potential
    effect modification. The injury analyses illustrate this
    distinction: I² exceeded 97% and prediction intervals were extremely
    broad, indicating that different surveillance settings may yield
    substantially different estimates despite addressing the same broad
    outcome. Similar considerations apply to physiological and
    performance measures, where indiscriminate cross-sport pooling may
    obscure meaningful differences. Future research should therefore
    move beyond estimating average effects alone and identify the
    athlete-, sport-, equipment-, and protocol-level characteristics
    that explain variability.</p>
  </sec>
  <sec id="implications-for-research-and-practice">
    <title>4.8 Implications for research and practice</title>
    <p>The next phase of Paralympic sport science should focus as much
    on improving the structure of the evidence base as on increasing its
    volume. A major priority is more complete and standardized
    reporting. At minimum, studies should clearly describe sport,
    eligible impairment, sport class, sex, competitive level, equipment
    configuration, test protocol, and the relevant exposure or sampling
    denominator. Without these variables, apparently similar studies may
    be difficult to compare or interpret.</p>
    <p>Methodological harmonization is also important. Elite Para-sport
    populations are often intrinsically small, which limits the capacity
    of single-center studies to support class-, impairment-, or
    sex-specific inference. Multicenter collaboration, shared data
    dictionaries, harmonized protocols, prospective registration, and,
    where feasible, individual-participant-data approaches could improve
    precision without forcing non-comparable athlete groups into the
    same analysis. Greater representation of women, athletes with
    intellectual impairment, and less-studied Paralympic disciplines is
    also needed.</p>
    <p>Evidence synthesis itself should also improve. Future systematic
    reviews should distinguish direct competitive Para-sport evidence
    from broader disability-sport evidence, prospectively register
    protocols, report complete searches and exclusions, integrate
    risk-of-bias judgments into interpretation, and account explicitly
    for primary-study overlap. For applied interpretation, the most
    consistent conclusion across domains is that health, physiological,
    testing, and biomechanical data should be interpreted within the
    sport, impairment, class, sex, equipment, exposure, and protocol
    context from which they were derived. Broad Para-sport averages may
    provide descriptive context, but the present evidence does not
    support their use as universal benchmarks across athlete
    populations.</p>
    <fig id="tbl-evidence-gaps">
      <caption><p>Table 5: Evidence gaps and research
      priorities.</p></caption>
      <table-wrap>
        <table>
          <colgroup>
            <col width="33%"/>
            <col width="33%"/>
            <col width="33%"/>
          </colgroup>
          <thead>
            <tr>
              <th><bold>Gap</bold></th>
              <th><bold>Why it matters</bold></th>
              <th><bold>Priority action</bold></th>
            </tr>
          </thead>
          <tbody>
            <tr>
              <td>Incomplete population reporting</td>
              <td>Results cannot be assigned confidently to sport,
              class, sex, or impairment.</td>
              <td>Minimum reporting set for sport, class, impairment,
              sex, level, and equipment.</td>
            </tr>
            <tr>
              <td>Small single-center samples</td>
              <td>Low power and limited subgroup analysis.</td>
              <td>Multicenter prospective cohorts and shared data
              dictionaries.</td>
            </tr>
            <tr>
              <td>Non-standard outcomes</td>
              <td>Similar constructs cannot be compared or pooled.</td>
              <td>Sport-specific core outcome sets and harmonized
              exposure definitions.</td>
            </tr>
            <tr>
              <td>Classification validity gaps</td>
              <td>Reliable impairment measures may not explain activity
              limitation.</td>
              <td>Link impairment measures to task-relevant performance
              across classes.</td>
            </tr>
            <tr>
              <td>Underrepresented sports and athletes</td>
              <td>Evidence maps are dominated by wheelchair sports and
              male samples.</td>
              <td>Targeted funding for less-studied sports, women, and
              intellectual impairment.</td>
            </tr>
            <tr>
              <td>Weak review methods</td>
              <td>Searches, exclusions, overlap, and risk of bias are
              incompletely reported.</td>
              <td>Prospective protocols, PRIOR reporting, item-level
              appraisal, and overlap matrices.</td>
            </tr>
          </tbody>
        </table>
      </table-wrap>
    </fig>
  </sec>
  <sec id="strengths-and-limitations">
    <title>4.9 Strengths and limitations</title>
    <p>Strengths of this umbrella review include its prospectively
    registered protocol, broad multidisciplinary scope, explicit
    separation of review-level synthesis from secondary quantitative
    re-analysis, assessment of methodological credibility and
    primary-study overlap, and use of prediction intervals to complement
    pooled injury estimates. The review also preserved the distinction
    between absolute and body-mass-normalized VO<sub>2</sub>peak and
    avoided constructing a universal cross-sport physiological
    benchmark.</p>
    <p>Several limitations should be considered. The review-level
    evidence was unevenly distributed across sports and was concentrated
    particularly in wheelchair and seated disciplines. Many included
    reviews combined sports, impairment groups, classes, sexes,
    competitive levels, and equipment conditions, limiting the
    directness of findings to specific athlete populations. ROBIS and
    AMSTAR 2 identified substantial methodological limitations across
    the review corpus. Primary-study overlap was moderate overall, and
    overlap estimates were limited where primary-study identifiers were
    incomplete or could not be matched confidently. The injury and
    VO<sub>2</sub>peak re-analyses were restricted to primary studies
    already represented in the source reviews and therefore should be
    interpreted as secondary re-analyses rather than updated
    primary-study meta-analyses. Injury data were reconstructed from
    published material, and some incidence exposure values were rounded
    in the source. In the VO<sub>2</sub>peak dataset, some publications
    contributed multiple source rows; residual within-publication
    dependence therefore cannot be excluded, and k represents source
    rows rather than unique publications. Sparse sport categories,
    particularly those represented by one or two rows, further limit
    random-effects inference.</p>
    <p>Finally, a small number of prospective primary studies were cited
    in the Discussion to provide contemporary context for surveillance
    and applied interpretation. These studies were not incorporated into
    the umbrella-review corpus and did not contribute to any pooled
    estimate.</p>
  </sec>
</sec>
<sec id="conclusion">
  <title>5. Conclusion</title>
  <p>Paralympic sport science now comprises a substantial
  multidisciplinary review-level evidence base, but its distribution,
  methodological credibility, and applicability remain uneven. Across
  domains, health and performance outcomes were strongly dependent on
  sport, impairment, class, sex, equipment, exposure definitions, and
  testing protocols; secondary re-analyses reinforced this context
  dependence through wide injury prediction intervals and marked
  between-sport variation in VO<sub>2</sub>peak. Methodological
  limitations and moderate primary-study overlap further reduce the
  apparent independence of the literature. Progress will depend on
  standardized reporting, harmonized sport-specific methods, multicenter
  prospective research, stronger classification-validity studies, and
  better representation of under-studied sports and athlete groups.</p>
</sec>
<sec id="declarations">
  <title>Declarations</title>
  <table-wrap>
    <table>
      <colgroup>
        <col width="50%"/>
        <col width="50%"/>
      </colgroup>
      <thead>
        <tr>
          <th><bold>Author Contributions</bold></th>
          <th align="left"><bold>Nicola Luigi Bragazzi:</bold>
          Conceptualization, Methodology, Formal analysis,
          Visualization, Writing - original draft, Writing - review
          &amp; editing. <bold>Morteza Taheri:</bold> Screening, Data
          curation, Validation, Writing - review &amp; editing.
          <bold>Carlo Trompetto:</bold> Methodology, Validation,
          Supervision, Writing - review &amp; editing. <bold>Luca
          Puce:</bold> Conceptualization, Supervision, Project
          administration, Writing - review &amp; editing. All authors
          approved the final manuscript.</th>
        </tr>
      </thead>
      <tbody>
        <tr>
          <td><bold>Funding</bold></td>
          <td align="left">This research received no external
          funding.</td>
        </tr>
        <tr>
          <td><bold>Institutional Review Board Statement</bold></td>
          <td align="left">Not applicable; this study synthesized
          published literature and did not involve new human-participant
          data.</td>
        </tr>
        <tr>
          <td><bold>Informed Consent Statement</bold></td>
          <td align="left">Not applicable</td>
        </tr>
        <tr>
          <td><bold>Data and Code Availability</bold></td>
          <td align="left">The de-identified processed datasets,
          complete analysis tables, and analysis code supporting the
          findings of this study are available from the corresponding
          author upon reasonable request.</td>
        </tr>
        <tr>
          <td><bold>Acknowledgments</bold></td>
          <td align="left">The authors have no acknowledgments to
          report.</td>
        </tr>
        <tr>
          <td><bold>Competing Interests</bold></td>
          <td align="left">The authors declare no commercial, financial,
          or other relationships that could be construed as a potential
          conflict of interest.</td>
        </tr>
        <tr>
          <td><bold>Supplementary Materials</bold></td>
          <td align="left"><ext-link ext-link-type="uri" xlink:href="supplementary/supplement-01.pdf">Supplementary
          materials</ext-link>. Supplementary Table S1 presents the
          included-review corpus; Supplementary Table S2 summarizes
          ROBIS and AMSTAR 2 appraisal results; Supplementary Table S3
          summarizes primary-study overlap; Appendices S1-S3 report the
          database search strategies, full-text exclusion reasons, and
          reproducibility specifications for the secondary
          analyses.</td>
        </tr>
        <tr>
          <td><bold>Generative AI Disclosure</bold></td>
          <td align="left">Generative AI tools were used only for
          editorial preparation and formatting support. The authors
          reviewed and approved the final content and take full
          responsibility for the work.</td>
        </tr>
      </tbody>
    </table>
  </table-wrap>
</sec>
</body>

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